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FRANCISCO JUAN MARTÍNEZ MOJICA

FJM MojicaPERSONAL DATA

Senior Lecturer
Department of Physiology, Genetic and Microbiology
Electronic post: fmojica@ua.es
Telephone: 965903400  ext. 2161
Brief summary of work: DNA binding proteins. Regulation of gene expression. Structure of DNA. Genome organization in prokaryotes. Biological role of repeated DNA sequences.

UNIT OF INVESTIGATION 1

Structural and molecular analysis of organisms.


LINES OF INVESTIGATION

CRISPR-Cas Systems. Use of bacteriophages as an alternative to antibiotics.

GROUP OF INVESTIGATION

Molecular microbiology

PROJECTS OF RECENT INVESTIGATION
  • “Bacteriphage lysins as altenatives to antimicrobial treatment”. Entidad Financiadora: 7th Framework Programme, European Commission / 291815 Era-Net ANIHWAInvestigador Principal: Francisco Juan Martínez MojicaDuración: 2016-2019.

  • “Inmunización en bacterias: adaptación del sistema CRISPR-CAS I-E de Escherichia coli y Salmonella enterica”. Entidad Financiadora: Ministerio de Economía y Competitividad/ BIO2014-53029Investigador Principal: Francisco Juan Martínez MojicaDuración: 2015-2018.

  • “Caracterización del sistema CRISPR/CAS-Y de Escherichia coli”. Entidad Financiadora: Ministerio de Ciencia e Innovación/ BIO2011-24417. Investigador Principal: Francisco Juan Martínez Mojica. Duración: 2012-2014.

 

RECENT PUBLICATIONS

UA Institutional Repository: http://rua.ua.es/dspace/handle/10045/162?locale=en

Book chapters:

  • F.J.M. Mojica, R.A. Garrett. Discovery and Seminal Developments in the CRISPR field (2013). In: CRISPR-Cas Systems: RNA-mediated adaptive immunity in Bacteria and Archaea. Barrangou, R. and van der Oost, J. (Eds.) Springer-Verlag Berlin Heidelberg. Cap1. pp 1-31. ISBN 978-3-642-34656-9; DOI: 10.1007/978-3-642-34657-6_1.

Articles in Journals:

  • Makarova K.S., Wolf Y.I., Alkhnbashi O., Costa F., Shah S., Saunders S.J., Barrangou R., Brouns S.J.J., Charpentier E., Haft D.H., Horvath P., Moineau S., Mojica F.J.M., Terns R.M., Terns M.A., White M.F., Yakunin A.F., Garrett R.A., van der Oost J., Backofen R., Koonin E.V. (2015). An updated evolutionary classification scheme for CRISPR-Cas systemsNature Rev Microbiology, 13: 722-736.

  • García-Gutiérrez E., Almendros C., Mojica F.J.M., Guzmán N.M., García-Martínez J. (2015). CRISPR content correlates with the pathogenic potential of Escherichia coli. PLoS ONE, 10(7): e0131935.

  • Almendros C., Mojica F.J.M. (2015). Exploring CRISPR-mediated interference by transformation with plasmid mixtures: identification of target interference motifs in Escherichia coli. Methods in Molecular Biology, 1311: 161-70.

  • Almendros C., Mojica F.J.M., Díez-Villaseñor C., Guzmán N.M., García-Martínez J. (2014). CRISPR-Cas functional module exchange in Escherichia colimBIO, 5 (1):  e00767-13.

  • Mojica F.J.M., Díez-Villaseñor C. (2013). Right of admission reserved, no matter the path. Trends in Microbiolog,y 21:446-448.

  • Shah S.A., Erdmann S., Mojica F.J.M., Garrett R.A. (2013). Protospacer recognition motifs: mixed identities and functional diversity. RNA Biol, 10:891-899.

  • Díez-Villaseñor C., Guzmán N.M., Almendros C., García-Martínez J., Mojica F.J.M. (2013). CRISPR-spacer integration reporter plasmids reveal distinct genuine acquisition specificities among CRISPR-Cas I-E variants of Escherichia coliRNA Biol, 10: 792-802.  

  • Almendros C., Guzmán N.M., Díez-Villaseñor C., García-Martínez J. and Mojica F.J.M. (2012). Target Motifs Affecting Natural Immunity by a Constitutive CRISPR-Cas System in Escherichia coli. PLoS ONE, 7(11): e50797.

  • García-Heredia I., Martín-Cuadrado A.-B., Mojica F.J.M. , Santos F. , Mira A., Antón J. and Rodríguez-Valera F. (2012). Reconstructing Viral Genomes from the Environment Using Fosmid Clones: The Case of Haloviruses. PLoS ONE 7(3): e33802.

  • Kira S. Makarova, Daniel H. Haft, Rodolphe Barrangou, Stan Brouns, Emmanuelle Charpentier, Philippe Horvath, Sylvain Moineau, Francisco J. M. Mojica, Yuri I. Wolf, Alexander F. Yakunin, John van der Oost, and Eugene V. Koonin (2011). Evolution and classification of the CRISPR-Cas systems. Nature Rev Microbiology, 9: 467-477.

  • F.J.M. Mojica and C. Díez-Villaseñor (2010). The on-off switch of CRISPR immunity against phages in E. coliMolecular Microbiology, 77:1341-1345.  
        
  • S. Miquel, E. Peyretaillade, L. Claret, A. De Vallee, C. Dossat, B. Vacherie, E. Hajji Zineb, B. Segurens, V. Barbe, P. Sauvanet, C. Neut, J. Colombel, C. Medigue, F.J.M. Mojica, P. Peyret, R. Bonnet and A. Darfeuille-Michaud (2010). Complete genome sequence of Crohn's disease-associated adherent-invasive E. coli strain LF82. PLoS ONE, 5(9): e12714.

  • C. Díez-Villaseñor, C. Almendros, J. García-Martínez, and F.J.M. Mojica (2010). Diversity of CRISPR loci in Escherichia coli. Microbiology, 156: 1351-1361.

  • F. J. M. Mojica, C. Díez-Villaseñor, J. García-Martínez, C. Almendros (2009). Short motif sequences determine the targets of the prokaryotic CRISPR defence system. Microbiology, 155:733-740.

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